As chlorine is very electrophilic the profile of electrostatic charge through the entire molecule might be altered, forever or bad. Sterically it may also alter binding, but again substitutions in the para place have already been effectively tolerated in other cathinones which include 4 MMC.
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There is some change of belief no matter whether 4F-PHP truly stimulates the discharge of norepinephrine and serotonin, or simply functions to slow their reuptake, however it is known to interact strongly with All those methods.
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